One of the co-directors of Spider-Man 2, he is portrayed by Alfred Molina in a memorable performance that fans still fondly.
Into The Spider-Verse, which focused on the Miles Morales version of Spider-Man, reimagined Doc Ock as a woman, Olivia Octavius. Liv is the head scientist and CEO of Alchemax, as well as a scientific adviser to Wilson Fisk. Her character, who is later revealed as Doctor Octopus, tells Peter Parker that he will die of cellular degeneration if he continues to stay in the alternate dimension he finds himself in. Although Doc Ock was initially supposed to be male in the animated film, the directors decided to gender swap the character for a woman, allowing them to take elements of the classic Spider-Man story and twist them (something the movie does well).
Although Doc Ock wasn't the only classic Spider-Man villain to appear in Into The Spider-Verse, it seems that she might be the franchise's main big bad. In an interview with Total Film, co-director Rodney Rothman made a statement that hints that Doc Ock will serve as the villain in future stories set in the Spider-Verse. Rothman said:
"In the end, we found the movie played fine without us tagging every single possible thing. But we definitely think of Liv as someone who is not gone from the story, and who in many ways, is our most powerful bad guy. She's manipulating a lot of things to achieve her own grand ambitions."
Into The Spider-Verse received a good reception from both audiences and critics alike. Not only did the movie end up earning a Golden Globe for Best Animated Feature, but it a sequel is already being planned, along with an all-female spin-off movie.
Many Spider-Man fans have even gone so far as to call Into The Spider-Verse the best Spider-Man movie ever made. Fans who want to see even more of the film are encouraged to get it on Blu-ray, which features an extended cut of the film.
Source: Total Film