It also comes down to how fast it takes effect.

We all know Superman is really fast, so what if he is off planet and decides to fly down really fast and punch her in the face?

In the split Second it takes for him to cross the last hundred feet, or maybe even half a mile, whatever her range to notice someone in her vicinity and to replicate is,

Im sure its a distance short enough he can travel it in a blink.. so what is her adjustment time?

If he was magically teleported to her is it instantaneous or is there a delay a speedster could take advantage of?

Her whole character is BS though it's the ultimate "Should never happen in comics"

What if she was dropped into a room with a thousand mutants or super powered, again for just being Superior to Superman when he is a race not a mutant is itself a backlash.

But then you take into other things like the mutant abilities of mimic or synch.. or hell even rogue.

Just over the top nonsense on this one.