The MCU offers many interesting characters and relationships. Some are well-known and held in high regard by the fandom, like the pairing of Captain America and Peggy Rogers or Daredevil and Elektra. However, some pairings from Marvel Comics will likely never see the light of day in cinematic adaptations due to how odd they were.
While some pairs are too different to be compatible others are just plain wrong. Whatever the case, the contrasting couples remain interesting storylines from the comics even if the couples were all but doomed from the start.
Deadpool And Shiklah
With an eclectic taste in men, to say the least, the Queen of the Undead Shiklah was married to wisecracking Deadpool before moving on to her current significant other, Dracula. As weird as the Dracula partnership is, the marriage she had with Deadpool is even more bizarre. The couple even produced a child, a daughter named Warda whose existence has been hidden from Wade by Skiklah. Despite being warned by Blade that Shiklah is a monster, Deadpool gets into a relationship with her anyway that then deteriorates due to Deadpool becoming more of a good guy which she argues is not the type of man she married. Plus, she cheated on him with Werewolf by Night.
The Thing And Ms. Marvel
The Sharon Ventura version of Ms.Marvel (after Carol Danvers) had a relationship with Ben Grimm for a time in the 80s. When Ms. Marvel ed the Fantastic Four, a shuttle accident involving cosmic rays mutated Ms. Marvel into the She-Thing.
Friends from the start, Ms. Marvel and the Thing became romantically involved after the mutation. Things went sour for the pair though, when Ventura agreed to ally with Dr. Doom with the promise he would turn her back to her human form, upsetting Ben that she would ever collaborate with a villain.
Elektra And The Punisher
Despite being an assassin who has worked for the likes of Kingpin, Elektra was still a love interest for the Punisher, a justice-minded warrior against major criminals. The couple started things out as a physical relationship only but then morphed into a loving, if not macabre, relationship. Nevertheless, the loner nature of each of them in conjunction with the Punisher's moral rigidness and Elektra's proneness to duplicity proved to be too much for them to stand, eventually going their separate ways.
Daredevil And Black Widow
The romantic pairing of Daredevil and the Black Widow was unlikely and a bit strange due to the headstrong nature and independence both characters showcase, making it seem like a pair that would butt heads. Yet, for a time in the 70s, the pair were perfectly attuned to each other.
It started when Matt Murdock was Natasha's lawyer. The two eventually fell for each other and liked the idea that they could blend their hero and civilian lives together. It proved to not work out in the end though, with the pair ultimately being too different and clashing.
Captain America And The Wasp
In the Ultimates series, Captain America dates the Wasp after he beats Hank Pym for nearly killing her. Pym, in the Ultimates, has been notorious for his abusive behavior so many saw Janet's relationship with Captain America as warranted. However, in an odd twist, Janet found the generation gap between her and Steve to be too much and started seeing Pym again behind Rogers' back. Eventually, the Wasp left Captain America to go back to Ant-Man. It doesn't seem likely that this will ever be a plot point in any future MCU Phase 5 projects.
Invisible Woman And Namor
Anyone that isn't Reed Richards seems like a weird match for Sue Storm. Regardless, this was the case when the Invisible Woman hooked up with Marvel's answer to Aquaman, Namor. Their story starts out with Sue's discontent with a work-consumed Reed pushing her into a relationship with Namor; not exactly off to a great start for this couple. Namor then kidnaps Sue Storm for her to be his queen, but she was still in love with Reed, so they separate. Things last a little longer for the two in the Earth 772 version where Sue and Namor get married and have a child. However, the pairing in that universe also ends when Sue goes back to Reed.
Storm And Black Panther
Somewhat unpopular with fans due to the retconning that made this relationship and later marriage possible, the union of Storm and T’Challa was cemented in Black Panther Volume 4: #18 in 2006 when the pair got married. What was especially weird as well as frustrating to Storm fans was that the relationship made Storm subservient, which is in complete contrast to the character as a whole.
Also, Storm and Black Panther were mainly separate from each other a lot of the time anyways due to busy schedules working on different teams, the X-Men and the Avengers respectively. As a result, it wasn't that big of a deal when the marriage was annulled in 2012.
Doctor Doom And Scarlett Witch
One of the most powerful Marvel villains ever, Doctor Doom is the arch-rival of Reed Richards, with the Fantastic Four trying to thwart Doctor Doom's efforts to dominate the world. That doesn't mean that Doctor Doom doesn't have time for some romance though. In Avengers: The Children's Crusade, Scarlet Witch's willed into existence child Wiccan searched for her and found her engaged to Doctor Doom. The pair seemed to genuinely love each other even if Wanda had some rightful trust issues with Victor. In the end, things didn't work out, and Scarlett Witch would move on to another strange coupling with Captain America.
She-Hulk And Thor
Most would associate Thor's love life with the human object of his affection Jane Foster. Yet, this powerful Asgardian mythical god becomes entangled with She-Hulk in the 2020 Empyre comics that saw the Fantastic Four and the Avengers along with other superheroes coming together to prevent an invasion of the Kree/Skrull armada. While the pair seem to be compatible in their strength, power, and appearances, the relationship was very different from what viewers would expect from each of the characters who were mostly involved with regular people before this odd coupling.
Scarlet Witch And Quicksilver
The brother-sister duo of Quicksilver and Scarlet Witch are in a romantic relationship in the Ultimates series. Magneto's offspring, Scarlett Witch and Quicksilver's incestuous relationship is even widely known and seemingly accepted by the other characters in the series like the Wasp. The Ultimates series is meant to be in an alternate universe and separate from mainstream Marvel continuity. Nevertheless, it's a strange choice for the characters, to put it mildly.