Warning: This article discusses topics of substance abuse, violence, and death.

Dr. Gregory House in House’s first episode in 2004, it was established that the connection between the titular character and Wilson was like no other. However, House’s addictions and lack of tact weren’t the only things that caused friction between them.

Despite his own problems, House’s Wilson was a good person, and he often went above and beyond for House even when he didn’t deserve it. There weren’t many people who stood by House’s side, especially after he hurt so many, but Wilson was by far one of the most consistent people in his life. Even though he was strangely committed to helping his friend, there were several times in which House was unbelievably toxic to Wilson, who definitely didn’t deserve half of the chaos thrown his way.

7 Stealing The Prescription Pad

Season 3, Episode 1 - Meaning

There was no doubt that Wilson went too far to protect House, and it was quite absurd that he risked his medical license to provide the titular character with Vicodin. Wilson put his career on the line to help his close friend, yet House was selfish enough to take it even further. After his leg pain became even worse, House stole one of Wilson’s prescription pads in the season 3 premiere “Meaning” in order to get more drugs.

For any medical professional to do this was wild, but the fact it was in character for House didn’t justify it. What was even more shocking about this was that Wilson had finally taken a stand and refused to provide any more medicine to him.

He knew that he needed to let his rehabilitation work and that House’s begging was simply his addiction talking, but the toxic doctor wasn’t able to listen to Wilson’s rational thinking. House’s awful behavior not only impacted his own health but also caused Wilson to be investigated by Tritter, a moment in House that made viewers quit the show and forced him to close down his practice.

6 Lying About Wilson Having A Child

Season 8, Episode 16 - Gut Check

House’s prank on Wilson in the season 8 episode “Gut Check” was one of the several times that Gregory House was a complete jerk throughout the entire show. Wilson had already voiced his desire to have a child in the past after he’d suggested to Sam that she possibly get pregnant in season 7.

House announced in an argument that an ex-girlfriend of Wilson’s called to tell him that she was pregnant years ago, but he never told him. A shocked Wilson reached out to the mother and then met his 11-year-old son, Duncan. However, House eventually revealed that Duncan was an actor and that all of the stress he’d put Wilson through was a lie.

House’s actions weren’t always logical, but this terrible attempt at a prank was just cruel, even if Wilson was relieved in the end.

This was ridiculous and highlighted just how wild House’s escapades were, but what made this moment even more stupid was how committed he was to his so-called joke. House invested time in checking Wilson's acceptance of the news and even questioned Duncan's paternity in order to keep up the act. House’s actions weren’t always logical, but this terrible attempt at a prank was just cruel, even if Wilson was relieved in the end.

5 Convincing A Patient To Sue Wilson For Malpractice

Season 4, Episode 9 - Games

Wilson was generally a decent medical professional throughout every season of House, but he did have a slip-up in the season 7 episode “Games.” Wilson sought from House after he realized that he’d misdiagnosed his patient, McKenna, with cancer, but his friend and colleague truly didn’t care. House always jumped to shame his colleagues, but Wilson deserved at least some reassurance.

While that was disappointing enough, House proved that his unpredictable behavior often put his colleagues in jeopardy with one of his baffling lessons. Wilson didn’t hesitate to it his mistake, but he still felt guilty for being incorrect. In fact, he offered to repay the $6000 McKenna owed to his broker, which he believed he didn’t have to repay because he was dying.

However, House whispered in McKenna’s ear and fed the patient information. Unbelievably, House convinced McKenna to sue Wilson for malpractice. House’s reason was nothing short of manipulative, as he was more concerned that Wilson saved his money in case he needed to borrow it from him. However, House taking money from Wilson was a prominent occurrence in House, sadly.

4 Breaking Wilson's Wrist By Crashing Into Cuddy's House

Season 7, Episode 23 - Moving On

The heart-stopping final episode of season 7, “Moving On,” began with the fallout of a terrible crash outside Cuddy’s home. As the episode progressed, it was revealed that House had crashed his car through his ex’s dining room, which led to his hospitalization. While Wilson, who was with him during this moment, was relatively unharmed, his wrist was broken.

This was a result of House pushing Wilson out of the car and speeding past him so quickly that he fell to the sidewalk with a thump. Thankfully, there was no further damage to Wilson, although he was a little shaken. Even though Wilson’s injury wasn’t intentional, it was still an awful thing for House to do.

House and Cuddy was one of the most important relationships in House, but he was so fixated on seeing Cuddy with another man that he failed to act rationally, and he put everyone inside and outside in incredible danger. Wilson was always there for House through his breakups, and his split with Cuddy was no different, yet he was punished. If House had simply stopped for a moment or even bothered to send Wilson further away from Cuddy’s front lawn, he would have been safe.

3 Inadvertently Causing Amber's Death

Season 4, Episode 16 - Wilson's Heart

“Wilson’s Heart” proved that House’s highest-rated episodes were also the most tragic. Amber Volakis’ heartbreaking death occurred in the season 4 episode, following a tragic bus crash that also resulted in House being itted to the hospital. While Amber’s demise wasn’t directly House’s fault, he was to blame for her being in the bus crash.

House’s addictions often damaged those around him, but after Amber came to collect him from a bar, he forgot his cane. Amber brought him the cane to the bus he’d boarded, and minutes later, it crashed. Amber was already sick, but the combination of her injured kidneys and the medication in her system poisoning her organs further meant that there was no hope for her.

It was heavily implied that without the bus crash, Amber would have had some chance of survival. This was one of the few moments that House actually showed some remorse for his actions, but it was still horrifying. He shouldn’t have relied on others to pick him up when he was drunk, and the fact that he was initially looking for Wilson made it weigh even heavier on his conscience.

2 Almost Getting Wilson Arrested To Avoid His Father's Funeral

Season 5, Episode 4 - Birthmarks

House’s relationship with his father was a complicated one, especially when he deduced that the man who raised him wasn’t his biological parent. Despite this, Wilson encouraged House to attend John’s funeral in the season 5 episode “Birthmarks.” Wilson didn’t need to drive him there, especially as House was far from a good friend, but he gently pushed his friend to make peace with the strained connection he had with his late father.

However, House refused to let the day go as planned. As they ed a patrol car, House used his cane to slam on the accelerator, which caused them to be pulled over for speeding. This was an amazingly selfish move, and House happily allowed Wilson to get in trouble with the law just because he was stubborn.

What made “Birthmarks” one of the most stressful episodes of House was that the titular character was present for the last time Wilson dealt with the police. Although everything in Louisiana was sorted out, House knew that the situation could still be used against Wilson, but still felt that his father issues were more important.

1 Borrowing Large Amounts Of Money From Wilson For No Reason

Season 2, Episode 5 - Daddy's Boy

It was suggested several times throughout House that Wilson had loaned the titular character money, but it wasn’t until the season 2 episode “Daddy's Boy” that audiences learned how often it was. Over the years, Wilson gave House money on four occasions, the most recent being $5000.

However, in a later argument between the pair, House revealed that he only kept asking to see how far Wilson would go.

House spent thousands of dollars on a motorcycle, which was an astonishing amount to spend randomly on something so non-essential. However, in a later argument between the pair, House revealed that he only kept asking to see how far Wilson would go. Considering everything Wilson did to help House, this was a rather brutal and self-centered act from the genius doctor.

House clearly loved to do things for the sake of it, especially if it involved him indirectly mocking someone, but this just felt like a power play. He made matters worse by magically offering to repay Wilson after he found out that his parents had been invited to dinner, and he wanted to avoid meeting them as much as possible. House was a terrible friend to Wilson in House, but this nonsensical and manipulative move was one of the worst.